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However, the deadlines of the BioCreAtIvE challenge made it impossible to develop a reasonable way to correctly attribute class type to each entity in these dictionaries, and class attribution was a differential feature that we wanted CheNER to have.
Nevertheless, neither gender, nor KPS appeared to be a differential feature between GHE and GLE.
In summary, we have developed a Differential Feature Index that allows one to accurately and effectively identify the genes that change expression in multiple RNA-seq datasets.
In fact, the lack of overexpression of EGFR and SEC61G in GHE could imply that these two genes are a characteristic feature of Gbs in general, but not a differential feature of primary Gbs.
For instance, DNA methylation profiles were shown to correlate with clinical parameters; specifically hypermethylation of GATA6 transcription factor was found associated with poor survival in GBM patients [ 35], or hypermethylation of the pro-apoptotic CASP8 is a differential feature of GBM relapses [ 51].
Triclabendazole (TCBZ, 6-chloro-5 2-3 dichlorophenoxy)-2-methyl thio-benzimidazole), an halogenated benzimidazole (BZD) thiol derivative, shows high efficacy against both the immature and mature stages of Fasciola hepatica in sheep and cattle, which is a differential feature compared to other available trematodicidal drugs [ 1].
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The tool is built on a non-parametric and unsupervised method using a metric called Differential Feature Index (DFI).
However, because detailed examination of genitalic traits did not reveal any differential features, Eupithecia goossensiata was downgraded to synonymy in a recent monograph on European geometrids [17].
To overcome limitations of current methodologies, we developed Differential Feature Index (DFI), a non-parametric method for characterizing distinctive gene features across any number of diverse RNA-seq experiments without inter-sample normalization.
Differential Feature Index (DFI) for a specific gene is defined as the variation of average pair-wise ratios between this gene and all the other genes across multiple samples.
Here, we introduce Differential Feature Index (DFI) to identify distinctive features across a large set of diverse experiments using read counts without any direct inter-sample normalization.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com