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The phrase "a different thing than" is not considered standard in written English; "different from" or "different than" are more commonly accepted.
You can use it in informal contexts, but it's better to use the standard forms for clarity and correctness.
Example: "This is a different thing than what we discussed last week."
Alternatives: "a different thing from" or "a different matter than."
Exact(22)
This is quite a different thing than intentional fraud".
"Yes, so it's quite a different thing than the thing I grew up with".
"Being a best-selling author is a different thing than being a professor," he said.
"If you are looking from the inside, you will see a different thing than you will see from the outside.
But saying America is a great nation is a different thing than talking about the current condition of the country.
Heart is a different thing than ability, and San Antonio has people on that team who can play".
Similar(38)
For example, a "cell" in a biological system can mean a very different thing than a "cell" in a mathematical model.
"Ten eggs for a 30-year-old is a very different thing than 10 eggs for a 40-year-old," Klein said.
If you're killing babies and taking the tissue, that's a very different thing than taking a dead specimen and keeping a record of it". If you had to reread that once or twice, you're not alone.
Reducing paperwork and duplication is a universal worthy goal, but that's a far different thing than construing an extra x-ray, pill or surgical procedure that doctor and patient want as unneeded.
"I think if you lobbied for a public interest it's a whole different thing than if you lobbied for a special interest," she said.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com