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An NMR structure of a single α-helical ARM bound to the IIB RNA hairpin has been known for quite some time (Battiste et al., 1996), and a second binding site in stem IA was identified that utilizes a different surface of the helical ARM from another subunit to recognize the RNA (Daugherty et al., 2008).
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Open image in new window Fig. 6 a Different surface charge of UCNPs-Ab conjugates at different concentrations of UCNPs, and b corresponding graph for surface charge versus UCNPs concentrations in UCNPs-Ab conjugate.
Furthermore, the CKS prosthesis has a different surface texture of the femoral component.
Attempts to establish if high level expression of a different surface protein on the surface of bloodstream form T. brucei could complement for lack of VSG synthesis were unsuccessful.
This stage of the parasite expresses a different surface coat, made up of a small family of proteins termed procyclins [ 5].
It is not clear at this stage if the elimination of the SPR signal is due to a different surface topology or because of different bulk properties of the composite layer.
Details of the interaction between wild-type CPXacc and t-SNARE must be different (they are also weaker, explaining why the wild-type CPX clamps less well), and we can well imagine a scenario in which wild-type CPXacc interacts with a slightly different surface of the assembling SNARE complex.
The jagged surfaces of the PCL/dex fibers were possibly a result of phase separation of dexamethasone and PCL, indicating that the PCL/dex fibers may have a different surface composition or distribution of dexamethasone than the PLLA/dex fibers.
Our mutagenesis analysis points to a different surface region (β3, L3, and β4) of the PH domain for Rab5 binding.
Sunday's – on his third different surface of the season – was his 30th victory of 2014.
Together, this work illustrates the utilization of different surfaces of a single immunoglobulin-like scaffold to generate binding proteins with distinct characteristics.
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