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Phage displaying a Fab specific for RSV-F protein with Fd linked to pIX showed efficient, antigen-specific enrichment when mixed with phage displaying a different specificity.
The assays may have a different specificity and sensitivity and the study population may differ between studies.
This task was undertaken with the aim to obtain new compounds with an enhanced antiproliferative activity and, possibly, a different specificity with respect to the original (lead) compound.
In this method, a sVD of a defined specificity is genetically fused to either the N-terminus of the light chain or the C-terminus of the heavy chain of a functional IgG antibody of a different specificity.
At a later stage, the immunoproteasome is expected to become expressed, which has a different specificity [46].
However, Pax6 5a) but not Ey(2a) could interact with the highly specialized recognition sequence 5aCON ([52], this study), suggesting that Ey(2a) might have a different specificity from Pax6 5a).
Similar(35)
Recently, we have found that the enzyme from Streptomyces coelicor has a very different specificity for activators and may fall into a new class.
There was no correlation of the taxonomic order, as, for example, the species from the order Rodentia, mice, rat and guinea pig, had a very different specificity of their UDP-glucuronosyltransferases (UGTs).
We agree that this can be interpreted as an indicator of different specificity, but we cannot estimate the depth of this difference.
The third enzyme found in Aspergillus nidulans, RmtB (AAR27791), revealed sequence similarities to human PRMT3 (O60678), but exhibited structural differences and a different substrate specificity and was therefore regarded as an enzyme unique to filamentous fungi (Trojer et al., 2004).
Collectively these reports highlight the potential contribution of nuclear importin α to various cellular events, each of which might involve a different substrate specificity, reflect cell-specific expression patterns and effect distinct transcriptional outcomes.
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