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It became the Great Depression because once a setback occurred, a financial system based on gold was so shaky that normal recovery was difficult and, perhaps, impossible.
A setback occurred when a typhoon struck the Haiphong area, destroying almost half of the refugee staging area.
A major setback occurred partway through the project when Dr. Chiang found he could gather data five times as fast if he recorded the neuron images in a different way.
But a major setback occurred in 1994 in the shape of the Kenneth Branagh movie Mary Shelley's Frankenstein.
A serious setback occurred when 18-year-old Jesse Gelsinger died in a University of Pennsylvania gene therapy trial for ornithine transcarbamylase (OTC) deficiency in 1999.
This the Campbells eventually achieved although a setback occurred during the Civil War when a Covenanter army under Sir David Leslie arrived on the island in 1647.
Another setback occurred in 2009, when a woman claimed to have suffered a head injury.
The most significant setback occurred on Wednesday, when a federal judge in New York refused to dismiss a batch of lawsuits brought against German companies by Holocaust victims.
Its biggest setback occurred in 2000, when a proposed three-way $140 billion deal to acquire the drug makers Warner-Lambert and American Home Products collapsed.
Heaney's third setback occurred in late March, a few days before the start of the season.
The same setback occurred three times, and after a magnetic resonance imaging test was performed on Tuesday and three specialists consulted, Gardner decided to have surgery.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com