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The phrase "a different route of" is correct and usable in written English.
It can be used when discussing an alternative method or approach to achieving something.
Example: "To solve this problem, we should consider taking a different route of analysis."
Alternatives: "an alternative path of" or "a different method of".
Exact(12)
At the same time, law firms enlisted by civil liberties groups have been rushing to establish a different route of challenging the detentions, by filing court petitions.
To study the effect of a different route of administration, 3×108 vp were injected intratumorally on three consecutive days in the RGDCRADcox-2R groups.
This could be a consequence of using a different route of inoculation (intranasal in Ref. 15).
A different route of duplication is restricted to single genes and occurs via RNA intermediates by the mechanism of retroposition.
A different route of adenosine formation during inflammation as compared with situations of ischemia could be an explanation.
First, the successful control of biopsy-induced bleeding was achieved by a different route of administration of TEA in all patients.
Similar(48)
The walking and cycling trail will take a different route, on the other side of Peachtree Creek and along quiet streets.
"If I had taken a different route out of all this, I'd be Miroslav Novotny," I say.
WhatsApp has taken a different route to most of its messaging rivals by charging users for continued use of its service, with a $0.99 per year fee on most mobile platforms.
However, if Hengnomics does succeed, there will at least be a different route to breaking out of the tyranny of demographics than money-printing and negative interest rates.
A different route for the catabolism of glucose also involves 6-phosphogluconate; it is of considerable importance in microorganisms lacking some of the enzymes necessary for glycolysis.
More suggestions(2)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com