The methods applied, especially the protocol #6 for sandwich ELISA, confirmed their sensitivity also in this cohort, that showed a different immunogenetic background and a different responsiveness to infection.
Second, our sample was predominantly male owing to the inclusion of a Department of Veterans Affairs hospital and it is possible, but unlikely, that females might have a different responsiveness to antibiotics from that of males.
This study was undertaken to better understand the in vivo interaction between lonidamine and cisplatin in the treatment of human tumour xenografts, including three carcinoma models characterized by a different responsiveness to cisplatin, in spite of the presence of a wild-type p53 gene in all tumours.
Cladribine inhibited cell proliferation of MM cells in a dose-dependent manner, although the three MM cell lines exhibited a remarkably different responsiveness to cladribine.
Additionally, the age-related and comorbidity-related heterogeneity in levels of soluble adhesion molecules, as well as sheddases, in healthy individuals and septic patients could be an expression of a different basal state, as well as different responsiveness in sepsis, potentially leading to discrepancies in pathophysiology and disease progression between neonates, children or adults.
This model permits a systematic analysis of whether distinct mechanisms are associated with different responsiveness to therapies, and may identify a unique signature associated with these pathways.
At the highest concentration of 400 μM, for six cell lines (CCSW-1, EGI-1, GBC, MzChA-1, MzChA-2 and TFK-1) almost no vital cells were measurable, whereas for BDC and SkChA-1 a certain amount of cells survived, indicating different responsiveness to EGCG treatment.
Differing disease conditions and/or treatments may show different responsiveness indices, and therefore the findings of this study should be considered preliminary.
The effect is characterised by a programming of the genome that leads to different responsiveness and adaptability of the gene expression machinery to chronic and acute environmental stimuli, i.e. nutritional supply.
The phenomenon will not only lead to underestimates of effect in studies using the SGRQ, but could lead investigators who are unaware of different responsiveness to spuriously attribute variability to differences in patients, interventions, intervention effects or methodological quality.
This model is at odds with findings on honeybee behavior as nectar and pollen foragers exhibit different responsiveness to sucrose, with nectar foragers having higher response thresholds to sucrose concentration.
