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All molecules adopted a different conformation in the crystal.
The presence of effector molecule E2 triggers a different conformation shift, that also activate the ribozymes (middle bottom).
In its extrusion phase, the TM domain of an EcAcrB protomer assumes a different conformation from the other two protomers (Sennhauser et al., 2007).
However, the active site metal has significant influence on the binding mode, because the amide takes a different conformation in the Ni II) form.
The helix to loop transition results in a different conformation for a number of amino acids (from residue 144 to 150), thus the two iron-coordinating residues (Glu144 and His147) move away from the di-iron site (Fig. 1E).
Therefore we reassessed performance by repeating the simulation starting from a different conformation (see Methods).
The results presented here showed, for the first time, a different conformation of the amino domain of the PTEN protein in neuron nuclei.
Even though the Rosetta designed sequence represents an energy minimum for the scaffold conformation, this does not mean that this sequence cannot fold into a different conformation.
The data suggest that, for eukaryotic cell penetration, penetratin does not acquire classical secondary structure but requires a different conformation compared to that in solution.
This may be due to a hyperactive PKA phosphorylating ERα on S305 and locking it into a different conformation in the presence of tamoxifen [17], [18].
A second possibility is that EGCG could bind to RNA bound form of RIG-I and induce a different conformation resulting in the release of RNA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com