Exact(2)
They also found a difference in virulence between a fluconazole resistant derivative H99 R64 and the parental H99 strain.
It is not known whether this is caused by a difference in virulence or difference in exposure to the two subspecies.
Similar(57)
Deletion mutants of xopB from Xcv did not show any difference in virulence, indicating it does not contribute significantly to virulence [ 42].
Here, we observed a difference in their virulence traits such as hemolytic activity, biofilm formation, protease activity, and clumping factor and protein A production.
Had we used parental strains with a greater difference in virulence, we expect that we would have identified more and/or larger QTL. A. fumigatus is heterothallic and shows quantitative variation in virulence related traits [12], [13], [14], [15], including virulence in G. mellonella [50], and thus it will be possible to cross strains differing in virulence in this species.
In our case it seems that Nocardia needs only a few generations to produce changes in its virulence, since after 40 subcultures we observed a remarkable difference in virulence.
The lack of any evidence for neurologic disease in any of the NMRCD cases studied from 1994 to 2003 (D. Watts, unpub. data) suggests a possible difference in virulence compared with epizootic IAB and IC strains.
We found a significant difference in virulence (defined as time-to-host-death-since-exposure; see Methods further below) among the five parasite isolates/clones, with isolates P1 and P2 being the most virulent irrespective of the infective dose used (Table 2, Figure 1).
These results provide insight into the factors responsible for the difference in virulence among the different S. suis 2 isolates.
Studies have reported that whether a bacterial genome carries prophage often determines the difference in virulence between pathogenic and nonpathogenic strains [ 37, 38].
We hypothesized that either the difference in regulation of virulence factors present in all the strains or differences due to novel ones present in virulent strains at cool temperatures must explain the difference in virulence at low temperatures.
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