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In fact, only 5.7% of the genome showed a difference in replication timing; 3.2% of the genome replicated later in LNCaP compared to PrEC (ΔWA < −25), and 2.5% replicated earlier in LNCaP compared to PrEC (ΔWA > 25) (Supplementary Figure 1g).
In this study, we did observe a difference in replication speed between original virus and virus passaged on KG1 cells, but sequencing is needed to determine whether the virus truly adapted to the cell line.
The incubation period of HEV (6 8 weeks) is generally considered to be somewhat longer than that of HAV (4 6 weeks), but it is not clear whether this represents a difference in replication rate or a difference in infecting dose of virus.
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This finding may have been caused by a difference in viral replication in bats of different species.
One plausible factor that may be contributing to life-stage specific differences in risks of carcinogenic transformation per unit dose is a difference in celife-stage specifics for relevant stem cells.
In earlier studies, TLR5 detection of Lp flagellin was shown to regulate early recruitment of PMNs to the alveolar space that results in organizing pneumonia at later stages without a difference in bacterial replication [ 4].
It has been observed that the difference in replication timing often corresponds to a different spatial localisation of DNA sequence in the nuclear architecture [1].
In contrast, the native and invasive strain showed no significant difference in replication in cultured mosquito, monkey or human cells.
In addition, there is apparently no difference in replication of the hepatitis virus after acute Q fever hepatitis [ 14].
The outcome measure was the difference in replication kinetics of FHV-1 or HHV-1 comparing various lysine concentrations.
The difference in replication rate between K.in and GWAS P-value increased as the definition of a hub gene became more stringent.
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CEO of Professional Science Editing for Scientists @ prosciediting.com