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Only 1.0 percentage point of this difference was explained by a difference in recurrence rate.
Notably, we did not observe a difference in recurrence rate between those receiving chemoradiotherapy (26%) and those receiving chemotherapy alone (15%).
15 16 17 Importantly, both possible explanations would primarily have resulted in a difference in recurrence of acute otitis media in the first six months of follow-up, which was not the case.
Assuming the proportion of patients who experience recurrence following RBL is 30% and following HAL is 15%, the sample size required to detect a difference in recurrence rates with 80% power and 5% significance is 121 individuals per group.
However, it is not known whether there might be a difference in recurrence rate between WBC reduced RBCs and RBCs with buffy coat, as some experimental studies have suggested [ 26], which would be more relevant to practice standards in the USA.
In order to be able to detect a difference in recurrence rate after anterior colporrhaphy of 25% or more (35% in women with a levator defect vs 10% in women without levator defect), with an alpha of 5% and a power of 80%, a population of 102 patients with at least POPQ stage II prolapse in the anterior compartment, of whom 41 (40%) women with a levator defect, will be sufficient.
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There was also a difference in CVE recurrence rates (18.6% vs 16.5% and 9.6%, respectively) (P < 01).
Another limitation is that there was a difference in arrhythmia recurrence detection methods (Holter monitoring, implantable loop recorder interrogation) and a difference in time intervals between follow-up visits in the centres.
Patients were randomised to receive post-operative breast radiotherapy or no radiotherapy, and the trial was designed to detect a difference in local recurrence rates of at least 5%.
This difference corresponds to a significant difference in recurrence failure free survival (p = 0.01).
We did not find statistical evidence to support higher recurrence risk in clade 2 strains (almost exclusively ST1/027/NAP1), although we had low power (<40%) to detect a significant difference in recurrence rates of 25%and30%0% (as observed).
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