The effect of experimental errors can be individually noticed from their gene expression measurements, which were presented as log2-based [ 32], and therefore a unit difference corresponds to approximately a two-fold difference in signal intensity.
It should also be noted here that the putative assignment of PTM in Table 2 is based purely on the consideration that mass increments of 14, and 28 Da are mono- and di-methylations, a mass difference of 42 Da corresponds to tri-methylation or an acetylation, and an 80 Da difference corresponds to phosphorylation [23], [24].
A negative twin pulse difference corresponds to a decrease in conduction latency for the second action potential or an increase in conduction velocity (i.e., speeding).
In a typical patient simulation, this difference corresponds to a 30 min earlier tmax for a 200 mg morning infusion of LCIG compared with a 200 mg oral dose (tmax 45 min for LCIG vs. 75 min for LC-oral).
Using this method, a positive difference corresponded to a functional decline.
The point estimates are similar in direction (i.e. a positive mean difference or standardized mean difference corresponds to a RoM greater than one, while a negative mean difference corresponds to a RoM less than one).
Based on the median overall survival of 26.4 months or ∼803 days in the sunitinib arm, a 10% or greater difference corresponds to 80 days or greater.
In fact, final fitness remained depressed 9 dbl/hr below that of the evolved wild-type; with a 15-min generation time for both phages, the difference corresponds to a nearly fivefold difference in number of offspring.
The risk difference corresponds to a good response, defined as a ≥30% reduction in pain from baseline.
Unlike AACs from anesthetized rats (Klausberger et al., 2003), AACs in our awake head-fixed mice clearly did not fire with the highest probability close to the peak of theta rhythm (180°), but in fact discharged at 251° (the 71° difference corresponds to a 25 ms delay for an average, 8 Hz theta with a cycle duration of 125 ms).
This difference corresponds to a Cohen's d of 1.1 indicating a large effect size and is statistically significant (p ≪ 0.001).
