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Boehm, M. & Slack, F. A developmental timing microRNA and its target regulate life span in C. elegans.
Supporting this hypothesis, a developmental timing assay, making use of the different maturation times for green fluorescent protein and red fluorescent protein, demonstrated that during mid- to late somite stages there is continuous cardiogenic differentiation in the ALPM.
Dr. Luo and his colleagues suggest that a mutation to a developmental timing gene responsible for this late-stage disengagement might have essentially locked Maotherium's ears into a permanent embryonic state, just as can happen with rare human craniofacial disorders like Treacher Collins syndrome.
Chick embryos therefore initiate ZGA with a developmental timing comparable with that in the zebrafish and Xenopus embryos, pointing to potential conservation in molecular mechanisms controlling ZGA in yolk-rich embryos.
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It could be that the Cro1 population has retained an adaptive developmental flexibility that has been lost in the SB strain that was maintained in the laboratory for many generations, often subjected to a rigid developmental timing and in absence of relevant pathogen pressure.
Both groups identified sugar produced by photosynthesis as an endogenous developmental timing cue for the juvenile-to-adult phase transition, with the sugar acting to modulate miR156 expression.
Heterochrony, or a change in developmental timing, is an important mechanism of evolutionary change.
LIN28/LIN-28 was first described as a heterochronic gene and a regulator of developmental timing in Caenorhabditis elegans (Moss et al., 1997).
Although two studies in Drosophila found evidence of constraint in larval development (Davis et al. 2005; Artieri et al. 2009), studies in vertebrates (Roux and Robinson-Rechavi 2008), and in nematodes (Castillo-Davis and Hartl 2002), have failed to find a clear pattern of DNA sequence conservation as a function of developmental timing.
It was originally identified as a regulator of developmental timing in the nematode, C. elegans, and was therefore regarded as a heterochronic gene (Reinhart et al., 2000).
The miRNAs were first identified to play a role in developmental timing of Caenorhabditis elegans in the early 1990s [11], [12].
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