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Homozygous mutant embryos show a developmental failure of the notochord and posterior mesoderm, and die at midgestation.
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Cantrell et al. [ 10] suggested an embryologic developmental failure of a segment of the lateral mesoderm around gestational age 14 18 days.
Numerous unsubstantiated explanations for this fault have been offered, such as early arrest of the Y cartilage and, more recently, a primary developmental failure of the posterior superior buttress of the acetabulum.
These observations indicate that the reduced size of the ICM at E4.5 and the absence of hypoblast are not due to retarded growth or differentation but are a result of developmental failure.
To fill the information gap between exposures to EDCs and the outcomes of developmental failure, an experimental model that enables us to investigate the early developmental stages is essential.
And although the regime seeks to appeal to sectarian divisions and invoke the threat of Iran in order to delegitimise dissent, the truth is that the discontent is found across Saudi society, fed by political repression and developmental failure, as a result of corruption, government malfunctioning, and the squandering of billions on arms.
The two different nuclear phenotypes underlie specific transcriptional and translational programmes central to the acquisition of a correct developmental competence or developmental failure [ 2932]2932]
Brain region specific neuronal volume deficits and different trajectories of neuronal volume modifications during the lifespan indicate that an integral component of this developmental failure is the desynchronized growth of neurons, and that this might be a major structural contribution to the autism phenotype.
A null mutation of GDF5 causes developmental failure of skeletal structure and intra-articular ligaments in mice [ 14, 15].
Various evolutionary events can cause structural changes in the DGEN of an individual that may result in "developmental failure".
Mizutani, E. et al. Abnormal chromosome segregation at early cleavage is a major cause of the full-term developmental failure of mouse clones.
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