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The phrase "a devastating condition" is correct and usable in written English.
It can be used to describe a serious or severe state of health or circumstances that have a significant negative impact.
Example: "The doctor explained that she was diagnosed with a devastating condition that would require extensive treatment and support."
Alternatives: "a severe condition" or "a catastrophic condition."
Exact(51)
SALT Iodine deficiency is a devastating condition.
End stage renal failure is a devastating condition that involves multiple organ systems in affected individuals.
DF: This is certainly a devastating condition for your poor dog.
Introduction: Acute lung injury (ALI) is a devastating condition that places a heavy burden on public health resources.
Paralysis resulting from spinal-cord injury is a devastating condition that currently affects just under 1.3 million Americans.
Background context: Spinal cord injury is a devastating condition in which clinical disability results from demyelination of white matter tracts.
Similar(9)
For some inherited disorders such as Huntington's disease and cystic fibrosis, where a change in just a single gene causes a potentially devastating condition, highly predictive genetic tests already available.
This is, of course, a natural and reasonable request, especially for patients faced with a sudden devastating condition following previously normal health.
Neovascular age-related macular degeneration (AMD) is a visually devastating condition resulting from choroidal neovascularization and secondary photoreceptor loss.
Either way, a drug that replaces the aberrant protein might counteract an otherwise devastating condition.
Loss of the talus is a rare but devastating condition.
More suggestions(15)
a detrimental condition
a terrible condition
a shocking condition
a deadly condition
a crippling condition
a destroyed condition
a devastating dismissal
a devastating day
a devastating disease
a lifelong condition
a devastating simplicity
a fragmentary condition
a physical condition
a devastating effect
a devastating knockout
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com