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Therefore, as explained in the Materials and Methods and Text S1, we used several procedures to ensure that the microscopy imaging and alignment were stable over the 3 4 hr period of luminescence observations and that any observed heterogeneity in the light output from individual cells was not a detection artifact.
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The Holter ECG signals (three channels) were read and analyzed using the Burdick Vision Premier Holter Analysis System, which includes algorithms for QRS labeling, arrhythmia detection, artifact identification, and data correction.
In previous studies examining animacy and change detection, artifacts and topographical landmarks are detected equally quickly (New et al., 2007).
After automatic spot detection, artifacts, such as dust on gels, were manually removed and the weaker spots (<0.1% of the whole gel volume) were eliminated.
We then analyzed how an increasing false positive error affects the distance to the reference set by simulating detection artifacts that were randomly distributed over the target region and added to a sample from the reference set.
After automatic spot detection, artifacts such as dust or cracks on gels were manually eliminated, and then the weaker spots (individually < 0.05% of the whole gel volume) were eliminated.
Our proposed solution for a general artifact detection method is motivated by the needs of EEG practitioners.
A fully automatic artifact detection is implemented in a scripting mode in our interface, using any of the algorithms described below.
For this purpose, an automatic artifact detection was computed, which excluded trials from further analysis if the standard deviation within a moving 200 ms window exceeded 40 µV in any channel.
In a semiautomatic strategy (http://sccn.ucsd.edu/wiki), the researcher uses automatic artifact detection algorithms for artifact detection and later "accepts" or "rejects" the detected artifacts manually.
Automatic correction of vertical eye movements [46] and an artifact detection algorithm were run for an initial sorting of trials.
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