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Neither immediate injections nor continuous application of BPY resulted in a detectable reduction of BM formation in the spinal cord.
Incubation of RV 1 in the presence of purified laccase and immobilized silica laccase nanoparticles resulted in a detectable reduction in absorbance at 560 nm.
Nevertheless, mice exhibiting only a modest decrease in HNF4α levels displayed a detectable reduction in HBV RNA and DNA levels while maintaining virtually normal growth and glucose homeostasis (Figure 1).
In addition, COX subunit II (mitochondrial encoded) protein levels were significantly decreased (∼20%) following 14 D of immobilization indicating that the suppression of mitochondrial regulatory components (e.g. transcription/translation pathways) results in a detectable reduction in the expression of the COX subunit II mitochondrial protein.
Delivery of siRNA #2 resulted in a more modest and delayed reduction in cSPLUNC1 expression, while administration of 10 nmoles of negative control siRNA did not result in a detectable reduction in cSPLUNC1 expression at any time point evaluated (Fig. 3A).
Collectively, our data suggest that in vivo silencing of the c-Rel molecule can be achieved by delivering c-Rel-specific siRNA with retroviral mediated transduction and that partial c-Rel-knockdown in vivo results in a detectable reduction in lymphocyte proliferative responses to a protein antigen.
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In contrast, three alanine mutants (Lys650, Lys653 and Arg691) did not show any detectable reduction in binding affinity: the first two mutants comprised residue changes located at the middle of α2, which is outside of the second positively charged region and the third mutant (Arg691) comprised a residue change located at α3 faces on the opposite side of the surface.
In contrast, ATF4-deficiency in Jurkat cells resulted in a modest reduction in ULBP1 mRNA and a barely detectable reduction in ULBP1 cell surface staining.
We show here for the first time that a long CAG repeat length in the KCNN3 gene leads to an electrophysiologically detectable reduction in SK3 conductance.
On the other hand, inhibition of Activin signalling during this period with SB43, led to an increase in Sox1 GFP and to a slight but detectable reduction of T::GFP expression by exposure to AC (Fig. 2D).
Notably, the time gap between phosphorylation of STAT1 protein (within a few minutes) and detectable reduction of S100A4 transcription (24 h) suggested that the latter response was not a direct effect of STAT1 binding to elements in the S100A4 promoter.
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