In conclusion, we demonstrate for the first time that CD25 expression status, combined or not with the transfusion requirements, serves as an easy-to-use predictor for outcome in late-stage MDS patients treated with azacitidine, a finding that deserves validation in larger cohorts.
But the sheer simplicity of the technique used by Rumpf and colleagues [ 1] is appealing and certainly deserves validation in a large-scale prospective study.
This novel approach deserves validation in prospective studies with cetuximab- or panitumumab-based therapies in mCRC prior to have an impact as clinical practice-changing.
Although it deserves validation, the proposed taxonomy may be applicable to other populations and chronic conditions to plan intervention studies.
This signature deserves validation in tumor samples of patients treated with Zalypsis, with clinical trials currently ongoing, and also suggests a potential benefit for the combination of Zalypsis with tyrosine kinase inhibitors, which warrants further studies.
As part of this consortium, spontaneous reporting systems emerged as a cornerstone for timely detection of signals (previously unknown drug event associations or increasing the frequency of known adverse drug reactions [ADRs]), which deserve validation and risk quantification through different sources such as healthcare databases.
I felt like an imposter; yet, confusingly, I also felt I deeply deserved the validation.
Three of the six classes generated accurate genotypes and deserved further validation: PHR, NMH and OTV classes.
However, given the small number of cases, our results may deserve further validation in a wider cohort.
It is likely that the discrepancy observed between the rate of cases scored as positive on cytology and on histology could depend on the small sample size deserving further validation in a larger cohort of patients.
