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Cardiomyocyte apoptosis induced by 5-HT was shown to involve MAO-A-dependent ROS generation, which led to upregulation of Bax and downregulation of Bcl-2 and subsequent mitochondrial release of cytochrome c [249].
This increased TRAIL expression is reminiscent of a recent report describing the TLR7 triggering dependent generation of killer PDC expressing TRAIL able to induce apoptosis of HIV-infected SupT1 cells [27].
In the spermatophytes ("seed plants"), the situation is reversed, and the gametophyte is the smaller and dependent generation.
There was no statistically valid difference between the time dependent generation of C5a fragment in the serum contacting the particle-free cryogels and the composites (Figure 5a,b).
Pyrite water slurries show surface area dependent generation of hydrogen peroxide only in the presence of EDTA, which chelates dissolved Fe(II).
Many studies have assessed the helper dependent generation of primary CTL responses [32].
The data suggest that ecto-ATPase dependent generation of extracellular Pi is involved in ATP-induced apoptosis of oesophageal cancer cells.
A time-dependent generation of C5a fragment indicated weak activation of the complement system.
Analysis of the cellular level of singlet oxygen showed a time-dependent generation of singlet oxygen induced by TL/10 radiation and ApoG2 treatment.
To determine whether loss of (d ATP might be responsible for the failure of stored cytosols to support the CC-mediated caspase activation, we added dATP back to the cytosols stored at 4°C for 5 days (Fig. 3A) or at −20°C for 15 days (Fig. 3B), and in every case, we observed a CC concentration-dependent generation of p35 caspase-9 and p24/p20 caspase-3 bands.
These findings point to a mechanism by which casp-dependent generation of Beclin-1-C creamplifyingplooping loop enhancing apoptosis upon growth factor withdrawal.
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