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Upon continuous MQ exposure we have documented a dose dependent delay of the parasite cell cycle, particularly among the two MQ less sensitive P. falciparum clones (3D7 and FCB).
5-fluorouracil provoked a dose dependent delay in S phase (3-30 μM, p < 0.05) in all three cell lines independent of their p53 status.
Regenerative axial dynamics due to variable depth of cut is incorporated through a functional description of the cut surface profile instead of a delay differential equation with a state-dependent delay.
Extensions of these procedures are obtained for systems in which there is a temperature-dependent delay between the time at which a link reaches its failure temperature and the time at which that link actually fails.
A more detailed analysis with different concentrations of C2 toxin revealed a time-dependent delay of intoxication by 10 μM of G1.
Gal-3 promoted a dose-dependent delay in the growth of encapsulated cells of C. neoformans (Fig. 6a).
In addition, larvae in the Pf-5 treatment groups showed a dose-dependent delay in the onset of metamorphosis relative to control-, Pf0-1-, and SBW25-treated larvae.
Systemic administration of the anti-mouse uPA monoclonal antibody, mU1, to tPA-deficient mice caused a dose-dependent delay of skin wound closure almost similar to the delayed kinetics observed in uPA tPA double-deficient mice.
On the contrary, an alanine substitution at this residue renders Chk1 defective and unable to execute a checkpoint-dependent delay when faced with UV or CPT-mediated DNA damage.
Notably, gene expression of early and intermediate genes exhibited a dose-dependent delay.
Moreover, a dose-dependent delay in glomerular basement membrane thickening, tubule-interstitial fibrosis, and glomerulosclerosis was observed.
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