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Significantly, fine tuning on the structural features of organic ligands, such as spacers, positional isomers, and substituents, can lead to a delicate regulation of the diverse network structures of CPs.
Thus, a delicate regulation of Cyp7a1/ CYP7A1 gene expression maybe very important for a stringent control of BA levels during liver regeneration.
ZIP4 is expressed either in roots and shoots, showing a delicate regulation to control the homeostasis of Zn, thus avoiding potential toxic effects of this micronutrient [ 15, 17].
A delicate regulation of this process is requisite for normal bone homeostasis, and an imbalance is often related to metabolic bone diseases in humans [ 2].
Interestingly, limb length reductions characteristic of Sox9 haploinsufficiency were partially resolved when RBPjk-dependent Notch signaling was completely removed, suggesting that a delicate regulation and balance of Sox9 expression is required to coordinate chondrocyte hypertrophy and cartilage growth.
This was the first comprehensive study of MMPs and TIMPs in the human CVF and the findings demonstrate a delicate regulation of proteases and their inhibitors during matrix remodelling and cervical ripening.
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Most importantly, this delicate regulation by WNT5B didn't limited in a particular cell model; it was fundamentally associated with patients' metastasis and disease-free survival in a larger population with breast cancer.
The acutely, delicate regulation of local-produced ghrelin appears to be a fine-tune mechanism modulating the balance between testicular homeostasis and early IR injury.
Overall, the delicate regulation of local-produced ghrelin appears to be a fine-tune mechanism modulating the balance between testicular homeostasis and testicular IR injury.
Base substitutes in the repeats of the palindrome reduced the affinity between RSP and the operator, and thus delicate regulation could be achieved.
Moreover, spine-localized polyribosomes are substantially increased upon potentiation11, indicating that there is delicate regulation of ribosome number/function to meet the demands of local protein synthesis.
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