"There's no good evidence in humans that COX-2 inhibition has a deleterious role in rheumatoid arthritis," he says.
Work in pancreatic beta cells has also demonstrated a deleterious role of Mst1 through the promotion of beta cell apoptosis and dysfunction that could contribute to insulin resistance [134].
When activated, platelets express CD154 and release a soluble form of CD154 [210]210]; CD154 may bear a particular responsibility as, for example, the CD154/CD40 dyad plays a deleterious role in ALI, including pancreatitis-associated lung injury [211, 212], and as it could be brought to lung microcirculation via PMPs.
Most of them indicated a deleterious role of worms on malaria immunity [2].
Intriguingly, TLR3 has been observed to play a deleterious role towards the host following pathogen challenge in several models.
Our work, and that of many other investigators, has demonstrated that platelets have a deleterious role in ECM [5], [7], [8], [10], [27], [35].
Our work has shown that in the context of ECM PF4 has a deleterious role in driving immune stimulation, including monocyte activation.
Considering its complex roles in regulating both angiogenesis and inflammation, we here hypothesized that TSP-1 may play a deleterious role in CLI, and therefore sought to investigate its function in a mouse model of CLI.
Although the IFN response plays a protective role during some bacterial infections, studies in murine models have suggested that IFNs play a deleterious role in defense against Chlamydia infections.
To this extent, the Multiethnic Cohort and Women's Health Initiative trials show an increased incidence of breast cancer in postmenopausal women receiving combined hormone therapy with estrogens and progestogens as compared to the women receiving estrogens alone, suggesting that progestins may play a deleterious role on breast cancer [3] [5].
These results demonstrate a deleterious role for this senescence-associated CKI on articular chondrocytes.
