Sentence examples for a deleterious point from inspiring English sources
"We hypothesized that for a given pair of targets that differ by a single point mutation, a set of mismatches could be identified in the guide RNA that would eliminate Cas9's activity on the normal sequence while maintaining robust activity on the one with a deleterious point mutation.
In a recent publication by Kägi and colleagues [39] it was demonstrated that a deleterious point mutation in mitochondria localized cysteinyl-tRNA synthetase (SYCO) and an ATP/ADP translocator AAC2 results in defects of polar nuclei fusion.
When s is small this is the same as the effect of a single deleterious point mutation in classical models of MA [ 6].
In contrast, a deleterious turning point appeared under an extreme high grazing level.
The results show that the Asx residues in the turn motif make a substantial contribution to the overall stability of the protein, and the Asx logical OR relationship defines a redundant system that can compensate for deleterious point mutations.
Notably, chloroplast genomes display an enhanced genetic drift and accumulate mildly deleterious point mutations [ 34].
In contrast, processes depending on DNA as a template will require other means to compensate for deleterious point mutations.
In an ideal world, clinicians would be able to remove cells with such deleterious point mutations right after they are created to fight diseases much more effectively.
Moreover, the repeated occurrence of apparently deleterious point mutations within this highly conserved region of GRM1 suggest these mutations are 'functionally recurrent' and may be amenable to therapeutic intervention [35].
The combined effects of the deletion and deleterious point mutations may explain the hearing loss in these nine probands.
In addition to the listed above indels we found two deleterious point mutations that had previously been reported (Table 2): one nonsense (c.4603G > T) with a frequency of 0.5%% and one missense (c.181T > G) with a frequency of 1%%.
