Sentence examples for a deleterious interaction from inspiring English sources

For an alternative binding interaction to be deleterious, the proteins need to have a deleterious interaction (as defined by biological fitness) and to have the potential to interact at the same time, in the same cellular location, at the right concentration [ 42].

Thus, targeting p75NTR could protect neurons from Aβ by at least three possible mechanisms: i) blocking a deleterious interaction between Aβ and p75NTR; ii) down-regulating deleterious signaling (calpain, GSK3β and c-Jun) which mediates Aβ toxicity; iii) upregulating survival signaling (AKT) which is normally inhibited by Aβ and which can antagonize Aβ mechanisms.

We observed 891 total deleterious interactions with 203 of the 238 genes whose null alleles are CHI with an actin null allele; 35 genes failed to recapitulate a deleterious interaction with any of the actin point mutant alleles despite interaction with the actin null allele (Table S2).

It was noted that, although there was no general agreement on the significance of single-strand breaks, the authors did consider these changes as indicating genotoxicity, as they were concluded to be the result of a deleterious interaction of OTA with the hereditary material of the cell (Kuiper-Goodman and Scott, 1989).

Whereas earlier studies have not uncovered any deleterious interactions between TPM and METH with respect to cognitive performance, attention, or concentration, TPM tends to enhance METH-induced increases in attention and decrease perceptual-motor function [ 22].

Alternatively, it is also possible that a deleterious synthetic interaction between daf-2 and H3K4 demethylases could lead to shortening of lifespan.

Understanding the key mechanisms underlying this deleterious interaction may provide opportunities for the design of effective therapeutic strategies.

However, if the deleterious interaction between the quantum register and its environment is subject to correlations between qubits and non-Markovian effects, more care must be exercised in the assessment of how errors accumulate, and how they may be corrected [36, 37].

This suggests that the deleterious interaction between RA fibroblasts and cartilage is mediated by CD44 on the fibroblast cell surface.

The deleterious interaction between the dual epidemics of TB and HIV has crippled the health systems of many developing countries.

In recognition of the deleterious interaction between these diseases, the World Health Organisation WHO) has developed guidelines for the collaboration of both modalities of care in the pursuit of a coherent, responsive and adequate model[ 3].