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Once 'activated', the endothelium can promote additional congestion through humoral, renal and cardiac mechanisms, resulting in a deleterious positive feedback loop [ 20].
Under such a scenario, SC populations would be very small and caught in a negative feedback loop between the accumulation of deleterious mutations and shrinking population size.
It is a 3D world in a feedback loop.
We're helping to sustain a perpetual killing machine, a feedback loop.
Hypotheses for this central/peripheral discrepancy include recruitment of NO from the brain towards the burn site, and/or a negative feedback loop blocking central NO because of its oxidative and free-radical deleterious effects [ 55].
Even in healthy lungs, MV may contribute to a positive feedback loop that starts with mechanotransduction (in lungs) at the epithelial and endothelial levels leading to a deleterious inflammatory cascade that might affect distant organs and systems [ 4- 6].
In a sense, they're caught in a feedback loop.
It's a perfect feedback loop.
There is a wicked feedback loop.
"It creates a positive feedback loop," Jalal explains.
"At some point, you'll have a negative feedback loop.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com