The fact that our indolotryptoline resistance-conferring V-ATPase mutants are largely compound class specific, while Zhf1 mutants confer resistance irrespective of the compound class, further suggests a model in which zinc toxicity is a downstream deleterious consequence of V-ATPase inhibition in the presence of indolotryptoline natural products.
A likely deleterious consequence of responding differently to additional ROS is a greater increase in the presence of persistent DNA breaks and the rapid accumulation of chromosome rearrangements compared to wild type mouse embryonic fibroblasts [ 22].
Disruption of functional connectivity between brain regions may represent an early deleterious consequence of these synaptic pathologies, potentially occurring prior to neuronal death and atrophy (Greicius et al., 2004; Rombouts et al., 2005; Hedden et al., 2009; Sheline et al., 2010).
This study shows that an aggregate comprised of 100% glass material can be produced without any deleterious consequences of alkali silica reaction, provided sufficient quantity of fine glass powder is used in the mixture.
Possible mechanisms of suppression by Hsp70 in RNA-mediated toxicity might involve a misfolded protein response triggered by deleterious consequence of the pathogenic repeat RNA.
The installation of additional positive charge also has the deleterious consequence of decreasing ribonucleolytic activity or conformational stability.
To the extent that these micronutrients are associated with health and longevity, this evidence documents yet another deleterious consequence of cigarette smoking on human health.
Together, these results confirm the deleterious consequence of frataxin deficiency on cell proliferation and survival.
This failure occurs despite the deleterious consequence of the persistent inflammatory reaction that leads to the decline of lung function and likely to fatal outcome of the disease.
Our data, not only show similar decrease in respiration, but also pointed out the downstream deleterious consequence of this deficit, such as decrease in ATP synthesis rate, proteasomal deficit, and α-synuclein accumulation.
