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9 11 16 These trials reported a delayed resolution of symptoms and prolonged time to bacterial clearance but no serious complications.
On the contrary, these mice exhibit a delayed resolution of the inflammatory process, with increased circulating levels of IL-6 and serum amyloid A, and a tendency to develop more severe joint damage.
We observed that both ob/ob and db/db mice exhibited a delayed resolution of the inflammatory process and an increased acute-phase response during zymosan-induced arthritis compared to their lean littermates [ 90].
However, in later stages synovial hyperplasia, inflammatory infiltration and cartilage damage were generally greater in ob/ ob mice than in controls, suggesting a delayed resolution of arthritis in leptin-deficient animals (Fig. 2b,2c).
The length of mechanical ventilation and ICU stay were increased for EnCAP compared to CAP, with only a trend towards a delayed resolution of septic shock (as measured by the length of vasoactive drug use) and an increase in hospital mortality.
A delayed resolution could be a significant contributory factor to the observations that older people have less diverse repertoires, because if the effects of a single challenge can still be seen a month later, then the multiple challenges we encounter as part of everyday life could present a significant compromise to the baseline diversity.
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Is this delayed resolution simply a function of their acute illness, or do our current therapies add significantly to this problem [ 26]? Recovering patients may fester in bed for too long, accelerating bone and muscle loss.
13 In this context, the pro-resolving nature of AnxA1 has been demonstrated in a variety of experimental settings, noting induction of apoptosis, promotion of efferocytosis and tissue repair, spanning from models of acute inflammation (eg, 14 15) to a model of colitis where delayed resolution was observed in AnxA1−/− mice.
Defects or delays in their production result in delayed resolution, prolonged inflammation and increased tissue damage.
Since the morbidity associated with T. cruzi infection of WSX-1-/ mice is mediated, in part, by the development of aberrant Th2 responses, it is possible that a similar mechanism may contribute to the delayed resolution of Leishmania infection in these animals.
This delayed resolution is mediated by an interferon-γ (IFN-γ -dependent response that IFN-γ -dependentIFN-γ -dependention and continues thresponse thatapy.
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CEO of Professional Science Editing for Scientists @ prosciediting.com