Exact(1)
This is illustrated by a delayed replication of several pluripotency-associated genes in XEN cells (for example, Rex1 and Sox2) and the early replication of PrE-associated genes Gata6 and Foxa2 and is in keeping with the idea that some tissue-specific genes may replicate earlier when transcriptionally active [ 29, 30].
Similar(59)
DNA replication and DSB formation are coordinated at the local level, because delayed replication of a single chromosome arm delays DSB formation on that arm (Borde et al., 2000).
We have suggested that a key consequence of the delayed replication of the +3.5 G4 motif in rev1 cells is the uncoupling of the helicase and leading strand polymerase to create of post-replicative gap.
Altogether these observations clearly indicate that a common feature of CFS is delayed replication, substantiating the hypothesis that CFS are regions intrinsically difficult to replicate.
The replication pattern of FRA3B and FRA16D sequences strongly suggested that late replication or delayed replication progression is a determinant factor in FSs expression (Le Beau et al, 1998; Palakodeti et al, 2004).
In contrast, HT-29 suffered delayed replication in vivo with only a proportion displaying full VACV gene expression at day 21 (2 of 4 in either case).
Gal-3 functions in host defense against C. neoformans more by interfering with fungal physiology through delayed replication, capsular binding, and vesicle disruption than by its effects on the inflammatory response.
These results suggested that the silencing of RBM24 stimulated the initial translation of HCV proteins but inhibited and delayed replication of HCV genome.
It is generally agreed that fragile sites comprise regions of high DNA flexibility and display delayed replication [12], [13].
In particular, this is presumably the case for origins that show delayed replication due to the chromatin state of the chromosomes [27] or to the Cdk1-Clb5 activity [43], [44].
Also, ECs cultured in HG show delayed replication, abnormal cell cycling, and increased apoptosis.
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