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For both transcription factors, nevertheless, it should be noted that a definitive link between critical cysteine(s) modification, which may be irreversible or reversible, as a consequence of covalent binding or GSH depletion, and a change in activity still remains to be determined experimentally.
The difficulties of designing a trial are discussed and modifications that would allow a definitive trial to take place are suggested.
We are now aware about the minor modifications that are required to proceed to a definitive clinical trial employing the ASICA intervention.
By combining this approach with an advanced mass spectrometer (e.g., ETD-MS/MS), the accurate modification sites on O-GlcNAcylated proteins can be identified, which would be a definitive indicator for the protein O-GlcNAcylation status.
"Is it a definitive study?
A definitive treatment.
"There's nothing unusual about there being an ongoing negotiation and modification of terms of a collective bargaining relationship and even more so with an MOU because it's not a definitive document," he told the Guardian.
Such a definitive pronouncement could be premature.
The answer was a definitive yes.
There was a definitive curvature effect on tulip flame development.
He never settled on a definitive answer.
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