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In its role as a complementary methodology DiCE does not propose a definitive endpoint or establish a single criterion for association.
Like all of the studies described above, a study of this kind is not a definitive endpoint, but it does add to the body of RDS evaluation literature and may alert researchers of issues to be aware of when designing RDS studies.
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A true definitive endpoint would be the probability of death from prostate cancer.
In the poem "On Being Twenty-Six," Larkin was already envisioning the dismal and definitive endpoint: "Talent, felicity —/these things withdraw,/And are succeeded by a dingier crop/That come to stop".
Time to event is the clinically definitive endpoint in Phase III trials of new treatments of cancer, cardiovascular and many other diseases.
Obviously he changed the way people engage with music, information, news and entertainment, but his legacy also changes the way people engage (or don't) with one another in public spaces: people are "talking" via NFC tags to advertisements and store windows as much as they are to one another; the texture and rhythm of our working day now has no definitive endpoint; and so on.
Such endpoints would be used as surrogates for the definitive endpoint.
The weakness of this endpoint results from the difficulty in distinguishing between tumor-related and treatment-related clinical and imaging changes, and this may make this endpoint quite unreliable, with survival potentially being the only definitive endpoint.
When early indicators are strongly positive, but an effect on definitive endpoints has not yet been established, we need to find a way to announce these early findings without damaging the chances of obtaining the conclusive results that the trial set out to provide.
What are initially presented by partisan proponents as definitive endpoints turn out to be just turning points in a much longer saga, with startling new directions for the inquiries.
However, it remains unknown if they can predict more definitive endpoints, such as PCSM.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com