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In this series of 168 patients diagnosed with locally recurrent T1-2 NPC and previously treated with a definitive dose of radiation, high-dose re-irradiation with 3D-CRT, IMRT, BT, and BT with external radiotherapy is feasible and efficacious.
All researchers have concluded that retreatment using IMRT is feasible and tolerated for patients who have experienced a definitive dose of radiation using a conventional technique for their primary treatment of NPC.
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However, once infected, the proportion of animals that developed complicated UTI in response to varying inocula of U. parvum did not show a definitive dose response effect.
Furthermore, in a recently published study of more than 400 NPC patients with N0 disease who were treated with definitive dose of radiation to the primary and upper neck fields (levels II, III, and Va) only, recurrence out of the radiation field at the level IV neck region and supraclavicular area occurred in only one patient [ 34].
However, there is little consensus with regards to the definitive dose, efficacy or duration of treatment of these agents in comparison to each other [ 3].
The survey did not stipulate a definitive definition of SDM.
For this simulation exercise it was explicitly not our aim to derive definitive dose regimens for this infection, but only to provide a motivating proof of concept example.
Whichever approach is chosen, frequent antimalarial blood concentration measurements should be made in an attempt to characterize the PK-PD responses, as this would help inform design of the definitive dose-finding studies.
We sought to determine the optimal follow-up duration by analyzing the medical records of 25 patients with 39 HCC lesions who received definitive helical tomotherapy at a daily dose of 2 to 4 Gy at 5 fractions per week, for a total dose of 40 to 60 Gy, between January 2008 and January 2013.
For simplicity, this example did not consider dose individualization of warfarin dose to achieve the INR target since this example is to show an application rather than a definitive review of warfarin forgiveness.
For the purpose of this analysis, definitive CRT was defined by a planned dose of external beam RT of ⩾45 Gy delivered with chemotherapy, at least partly given concurrently.
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