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While HIA predictions alone would not be sufficient for a definitive assignment of pathogenicity, except for some key residues with critical functional roles such as 255G>A (m.902G>andand 533U>G (m.1180T>G), the method does provide a robust indicator of disruptiveness for a large group of mutations lacking direct evidence regarding their role in mitochondrial dysfunction.
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Although our data do not permit a definitive assignment to be made of the progenitor cell(s) from which polyps develop after LKB1 deletion, the rapid turnover of mature L cells (4 5 days) and inability of these cells to divide (Petersen et al., 2014) would seem to make these less likely candidates as the immediate precursor.
To ensure our results, Raman scattering is also performed for a more definitive assignment of the structure [26].
The two enzymes are part of the same enzyme family, making a definitive assignment difficult.
Morris used a question mark in his work because no complete crest had been found for his species, and without it a definitive assignment could not be made.
For example, some genes found in the metagenome data were of insufficient length relative to a specific query sequence to make a definitive assignment.
The small numbers in our study preclude the definitive assignment of association genes with response, but these results have identified a significant list of plausible candidate markers that should be validated in larger clinical data sets.
Methylotrophic methanogenesis has been hypothesized in the Ca. 'Verstraetarchaeota'50, although the lack of cultivation information precludes definitive assignment of this functionality.
Furthermore, the 1997 discovery of titanosaur embryos in Megaloolithus patagonicus eggs from the Auca Mahuevo locality in Argentina allowed the first definitive assignment of Megaloolithus eggs to titanosaur sauropod dinosaurs [10], [11].
Hybridization of these genetically mapped markers to switchgrass chromosomes would lead to definitive assignment of linkage groups.
This strategy is designed to enable definitive assignment of the amide of residue i+1 by recording the H N plane of an HNCO.
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