The phrase "a definition of dose" is correct and usable in written English.
It can be used when discussing the meaning or explanation of the term "dose" in various contexts, such as medicine, pharmacology, or radiation.
Example: "In this study, we will provide a definition of dose to clarify its significance in treatment protocols."
Alternatives: "an explanation of dose" or "a description of dose".
As a starting point for realizing this aim, we have adopted a definition of "low dose" in the sense of "low-effect doses," that is, doses associated with small responses.
We searched for a definition of rapid dose escalation using keywords "antipsychotic", "neuroleptic", "rapid dose escalation", "rapid titration", and "rapid increase".
We adopted a broad definition of dose investigation study to include clinical trials that a) state a dose finding objective in the opinion or are cited as informing dose choices for subsequent trials or b) compare two or more dosing rules or c) measure PK end points.
We used a real-world definition of dose escalation (syringe/vial increase or shortened frequency of dosing) and a method used in other studies [ 13, 22] (average weekly dose) to compare patterns across etanercept and adalimumab.
We excluded from our definition of dose investigation study a) pre-clinical studies (including ex vivo studies), b) bioequivalence trials, c) therapeutic dose monitoring (TDM) trials without a stated dose finding objective and d) efficacy bridging studies not making explicit mention of pharmacological modelling.
Based on animal models suggesting that maximal anti-tumoral was achieved with 15 infusions it was decided to include the number (Nb) of infusions in the definition of Dose Levels to confirm the good tolerance of a growing number of OM-174 injections.
As a result of discussions regarding cardiac toxicity seen in some early patients, the definition of dose limiting cardiac toxicity was revised during the study.
We briefly reviewed one definition of dose addition, which is applicable within the framework of generalized linear models.
We established how this definition of dose addition corresponds to effect addition in case only two doses per compound are considered for evaluating synergistic effects.
The main problem with prescription of drugs to children is: choice of drug and definition of dose.
