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The phrase "a defining role of" is correct and usable in written English.
It can be used to describe the significant or essential function that something plays in a particular context or situation.
Example: "Education plays a defining role of shaping an individual's future opportunities and success."
Alternatives: "a crucial function of" or "an essential part of".
Exact(4)
In spite of such a defining role of chirality, most synthetic methods yield a broad distribution with mixed properties.
Our results revealed a previously unrecognized role of outer cell microtubules and the Golgi apparatus during invasion and supported a defining role of lysosomes of inner and outer cells for degradation of internalized cell.
That is, there is no correlation of gene cluster sequence with the general class of host colonized, arguing against a defining role of any particular cluster in determining host specificity.
"My defining role is being a character actress and telling the stories of forgotten women.
Similar(56)
The topography within the catchment was found to play a defining role for NDVI values.
However, he played a defining role in many of the conversations we engage in every day.
James resorts to what he believes to have been the greatest discovery of modern psychology, namely that subconscious forces play a defining role in the life of an individual, even when they have no conscious awareness of them.
As described above, workload plays a defining role in the level of productivity and quality that can be expected of CHWs.
Sara Shettleworth has played a defining role in the development of animal cognition and its integration into other parts of biology, especially behavioural ecology.
Gaddafi played a defining role in the rebuilding of the modern Libyan nation.
Among them were leading scientists who played a defining role in the emergence of American atomic discovery and the computer age.
More suggestions(3)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com