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If, in the current study, the observed AUA during course one was below this defined target value of 23, the patient received a subsequent dose increase in order to achieve an AUA value of 23 during the second course.
However to reach the defined target value (e.g. maximum allowed deviation of a gap-/ flushness- measurement) there are multiple input parameters available towards the tolerance simulation model, which can be modified to a certain range.
The traffic light evaluation has to be discussed against the background of the defined target value in 2020 and the ongoing debate on bioenergy.
The four criteria considered can be seen in Table 2, including the defined target values and the applied weighting factors for each criterion.
The objective of that wide-ranging investigation was to define target values for all indicators of the SIS in a comprehensive and reliable way.
If the difference is less than the defined target threshold value, no additional volume is needed and the next VNA delta is measured 60 min later.
In this respect we previously published a case report of a preterm infant treated with carboplatin, highlighting the potential for marked changes in drug clearance with age and requirement for increasing doses of carboplatin to achieve defined target AUC values [17].
From there, write a basic hypothesis of how your product/service can provide value to a clearly defined target customer.
Dose adjustment was carried out based on observed individual daily AUC values, to obtain the defined target exposures.
It seems to be worthwhile to study platinum-DNA adduct formation in a larger group of patients to define target adduct values that may be used for individual dose escalation.
Furthermore, it presents several alternatives for defining the bounds of the ALARP region to define target reliability values.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com