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However, random mutagenesis, used in TILLING approaches, provides only a limited density of mutational events at a defined target locus.
Dosage form development involves design and development of a product with a defined target product quality profile, and a defined manufacturing process.
Controlling the release of recombinant adeno-associated virus (rAAV) vectors from biocompatible materials is a novel, attractive approach to increase the residence time and effectiveness of a gene carrier at a defined target site.
It allows comparison of alternative solutions, understanding of their benefits and drawbacks, as well as the evaluation of the (remaining) distance to a defined target and, as a result, robust holistic decision-making for innovative sustainable process design.
Short peptides can now be rapidly selected, which exhibit the same, or higher, specificity and affinity for a defined target molecule, than (say) an antibody or even the natural ligand.
In order to perform a direct and easy quantification of transcripts on cell extracts, the feasibility of an analytical device able to selectively detect a defined target RNA in a complex mixture while avoiding labelling, retrotranscription and amplification steps, has been explored.
Similar(22)
Targeted re-sequencing: sequencing of a defined (targeted) region of the genome; helpful in identifying disease variant(s) when a linkage region has been established.
Stereotactic radiosurgery is a technique designed to produce a specific radiobiologic effect within a sharply defined target volume in a single session.
In contrast to a strictly defined target weight, some clinicians prefer a weight range of "around" the 25th age-adapted BMI percentile.
The sensation is not entirely a new one, but it was rarer in the days before the internet, when almost everything that made its way to broadcast had a calculated position within the schedule and a clearly defined target demographic.
Compared with the effects of HBx on HIF-1 α, a similar tendency of changes in NF- κB, a well defined target of HBx, was also observed.
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