Furthermore, as early disease is potentially curable, HCC meets some of the key criteria for screening; namely, a defined at-risk population and effective therapy for early disease.
Ideally, a meta-analysis would utilize input data only from studies with the same precisely defined risk factor, health outcome, and population.
15 Since all disease episodes occurring in a defined population at risk are included in this type of study, the potential for selection bias is minimised and calculation of unbiased incidence and mortality rates seems possible.
15 Population-based organised screening programmes involve inviting a defined population at average risk for the disease (ie, people who do not have CRC, or strong family history of CRC, or medical conditions that put them at higher risk of developing CRC such as Crohn's disease or ulcerative colitis) to attend screening.
However, a major limitation for defining this risk population is the absence of reliable biomarkers, which also affects the development of surveillance strategies and chemoprevention therapies for BE and EAC.
Last year, the United States Preventive Services Task Force ("USPSTF") determined that "annual screening for lung cancer... in a defined population of high-risk persons can prevent a substantial number of lung cancer-related deaths".
The risk analysis feature can be used to evaluate risk for a defined population of an aggregated small area (e.g., CBG), similar to SIR. The RR produced by the RIF is intuitive to investigators for interpretation.
The PECARN CDR defines a low risk population in whom cranial CT scans can routinely be obviated.
The CRS exhibited a high discriminatory power, defining a high risk population with an approximately fourteen times greater risk for XDR-PA colonisation.
The objectives of this retrospective study were to define risk factors of the population in whom HSV virus was isolated.
In this investigation we compared RIF risk analysis with the SIR method used by EEP to evaluate cancer risk in a defined population, and RIF disease mapping with SaTScan to explore for potential clusters of interest.
