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Here, we combined ab initio quantum mechanics/molecular mechanics studies and biochemical cleavage assays to show that Pol II utilizes downstream phosphate oxygen to activate the attacking nucleophile in hydrolysis, while the newly formed 3′-end is protonated through active-site water without a defined general acid.
An alternative, non-invasive approach using TE was employed to screen a defined general population for significant liver disease in France.
Using data from a 14-year follow-up study of a defined general Japanese population, we demonstrated that metabolic syndrome determined by the updated 2005 NCEP ATP III criteria was an independent risk factor for the development of type 2 diabetes in both sexes even after adjustment for comprehensive risk factors.
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By denigrating reason, celebrating impulse and advocating repression and tyranny in the name of a loosely defined "general will", Rousseau's thinking, argues Mr Blom, was actively maleficent (and, unsurprisingly, venerated by Robespierre).
But then, as Reichenbach appeared to have recognized in his comments about the "destruction" of the metric by gravitational fields, it cannot serve as a coordinately defined general standard for metrical relations.
In the UK, this collaboration between specialist CMHT services and general practice services is facilitated because each CMHT is aligned to a handful of defined general practices within the same geographical area.
(a) We define general terms, then discuss who makes our disability or blindness determinations and state that disability and blindness determinations made under other programs are not binding on our determinations.
SNPs were chosen based on the founder strain distribution pattern (SDP) as a means of defining general haplotype blocks (Yalcin et al. 2004a).
The results of the previous section may serve as a starting point for defining general star-shaped distributions.
We have defined a general signal model and identified a set of four signal parameters whose values characterize the transmitted signal.
Comparative transcriptomics defined a general core of genes upregulated as an early response to infection, which guided us towards the identification of unexpected systemic responses.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com