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A (Q SAR model for regulatory purposes should be associated with the following information: 1) a defined endpoint 2) an unambiguous algorithm 3) a defined domain of applicability 4) appropriate measures of goodness-of-fit, robustness and predictivity 5) a mechanistic interpretation, if possible. . a defined endpoint.
As ECHA's guidance reports [9] the OECD stated that 'to facilitate the consideration of a (Q SAR model for regulatory purposes, it should be associated with the following information: 1. a defined endpoint; 2.
The five OECD principles were: a defined endpoint; an unambiguous algorithm; a defined applicability domain (AD); appropriate measures for goodness-of-fit, robustness, and predictivity; and a mechanistic interpretation, if possible.
appropriate measures of goodness-of-fit, robustness and predictivity; 5. a mechanistic interpretation, if possible.' . a defined endpoint; an unambiguous algorithm; a defined domain of applicability; appropriate measures of goodness-of-fit, robustness and predictivity; a mechanistic interpretation, if possible.'.
In 2004, following five OECD principles for model validation were adopted to validate a QSAR model for its regulatory consideration: a) a defined endpoint; b) an unambiguous algorithm; c) a defined domain of applicability d) appropriate measures for goodness-of-fit, robustness and predictivity and e) mechanistic interpretation, if possible [3].
"Even though my homeless trek was only for a week, with a defined endpoint, that statement became much more real for me.
Similar(47)
However, a clearly defined endpoint using repeated-measurements ANOVA with a size of 10 in each group provided significant and robust results.
The skin sensitisation is a well defined endpoint of specific utility within the REACH framework.
The performance of clinical trials in which normal tissue injury is a clearly defined endpoint would greatly aid in realization of these goals.
Nucleos(t)ide analogues typically demand to be continued indefinitely to maintain viral suppression, without a clearly defined endpoint for stopping treatment.
Although amputation seems a clearly defined endpoint, there are several caveats in the study by Holman et al [ 1]; besides those discussed above, there are also methodological issues.
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