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This technique can be refined to define dosing thresholds for specific tumour types and treatments, but appears generally predictive even in a heterogeneous cohort.
Randomized control studies employing strategies to account for the pace of walking are needed to confirm these associations and to define dose-response thresholds of benefit in populations for which its use is intended.
Future studies will focus on defining absorbed dose threshold values for fusion dual-tracer SPECT dosimetry in a prospective controlled setting.
However, the erratic pharmacology of kratom makes it difficult to define a specific dose threshold.
No male contraception is required if the dose is below a defined threshold for genotoxic concern applicable to small molecules.
CT (Cycle Threshold) was defined as the number of cycles required for the fluorescent signal to cross a defined threshold of signal (i.e., up to background level).
A dose/response function is found which predicts the proportion of residents in an area whose reaction exceeds a defined threshold with a standard error of 4·6 dB.
where τ3 is a defined threshold.
7 Second, the threshold criteria defining tolerability in the 10 patients were unrealistically higher than the conventional criteria used to define dose-limiting toxicity in phase I trials.
For men, a dose threshold was absent.
9 CEM43°C seems an acceptable thermal dose threshold for most patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com