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The use of a defined challenge strain appeared to be advantageous in view of the extreme genetic variance of H pylori in patients.
Pre-ART loss to follow-up is a common but less clearly defined challenge in settings with limited resources.
The interpretation of human genome variation is a defining challenge in human biology for the foreseeable future.
The tragic events of recent days in Kyrgyzstan are not merely a matter of that country's political future; they pose a defining challenge for mutual security in the Eurasian region as a whole.
Giving every child a fair chance in life is a defining challenge for our generation, and it must be tackled head-on.
And, I have to say, the ideas posed problems and defined challenges but in that process we came close to giving up on a number of occasions.
For example, Eastern European millennials defined challenging work differently in the study, depending on where they lived.
PaTH was the result of a bottom-up process in which home care professionals, general practitioners, patient organisations, and hospital employees (nurses and physicians) defined challenges and proposed solutions in transitional care and follow-up [ 2].
Ex vivo response: (nutritional) intervention or comparison occurring in vivo ; cells or blood isolated from participants in a study is assayed for functionality using a defined in vitro challenge (e.g. phagocytosis, natural killer (NK) cell activity or production of cytokines by ex vivo stimulated peripheral blood mononuclear cells or whole blood).
In vitro response: (nutritional) intervention or comparison occurring in vitro ; cells or blood isolated from subjects not participating in a study is exposed in vitro to the compounds, nutrients and so forth to be compared and is subsequently assayed for functionality using a defined in vitro challenge.
I think the defining challenge in this country since the moment of its founding has been to figure out how a people — who even at our inception were so heterogeneous that European political theorists thought we could not succeed as a republic — can come together as a nation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com