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Each Assembly cohort comes together around a defined challenge.
The use of a defined challenge strain appeared to be advantageous in view of the extreme genetic variance of H pylori in patients.
Not surprisingly, it was found that markers that involve the standardised assessment of relevant symptoms (e.g. symptoms of common infections or allergies) or in vivo responses to a defined challenge with antigens or allergens (e.g. response to vaccination or allergen provocation) provide the most useful indication to interpret the modulation of immune function.
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These kinds of digital, ethical problems represent a defining challenge of the 21st century.
President Obama has called closing gaps of opportunity a defining challenge of our time.
Democratic nominee Hillary Clinton, on the other hand, said that the science on climate change "is crystal clear," and that it is a "defining challenge of our time".
In December 2013, Obama declared that growing income inequality is a "defining challenge of our time" and called on Congress to bolster the safety net and raise wages.
In a way, my book was really continuing the lines of recent discussions, that is to say, we've identified the problem and we've seen some of the reasons for it, and we've seen our political leaders and our religious leaders all saying this is a serious problem — a "defining challenge of our time" to quote your president.
Pre-ART loss to follow-up is a common but less clearly defined challenge in settings with limited resources.
One way to clarify is with crisply defined challenge questions.
"Africa is poised for a defining challenge," he said.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com