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The phrase "a defilement of" is correct and usable in written English.
It can be used in contexts discussing moral, physical, or spiritual contamination or violation.
Example: "The act was seen as a defilement of the sacred traditions that had been upheld for generations."
Alternatives: "a violation of" or "an affront to".
Exact(5)
And it's a defilement of sacred matters.
Palestinians see it as an affront to the Muslim tradition of immediate burial, and a defilement of their honor.
Grass called it an "insult," a "defilement of history," because among the thousands of graves were the remains of forty-nine Waffen S.S. soldiers.
Romanowski spent most of yesterday's session answering questions about the incident, not because it represented a defilement of sportsmanship, but because it lighted a fire that threatened to engulf the team.
He "preached a gospel of individual salvation and personal orderliness, construing civil rights activism as not only a defilement of social purity but even more as simply irrelevant to the proclamation of Jesus Christ as God.
Similar(55)
That kind of abuse of power, abuse of situation, abuse of position, that's a defilement of… my father.
Being forced to publicly remove the hijab, the lawsuit contends, "is a profound defilement of the wearer's sincerely-held religious beliefs and a violation of her religious practice".
In many places, the antimaterialist hippies' arrival stimulated a crass tourist trade and an attendant defilement of native culture.
An opening flashback makes it clear that an explorer's century-old defilement of an Egyptian tomb has triggered a delayed curse: an ancient tablet – resembling a keypad – is failing in its magical power to bring the museum exhibits to life.
For everyone else, this child represents the defilement of a purity to which we accord an almost sacred status.
It was a near thing, though, & if the sphere had found its mark, the incident would have been tantamount to defilement of a national monument, for Miss G. woman & girl, has very likely rendered "The Star-Spangled Banner" in line of duty more often than any other American We suggest that for the next soccer night at the Garden she be surrounded by an honor guard of alert Marines.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com