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Do we really want to ask women to replicate a fairly deficient model?
Previous work has shown that deflazacort treatment of the mdx mouse, a dystrophin deficient model of DMD, can alleviate symptoms of the dystrophic pathology and results in the stimulation of utrophin A expression in skeletal muscle fibers [6].
In skeletal muscle, insulin receptor phosphorylation and AMP-activated kinase activity were found to be enhanced in A-FABP deficient models, thus resulting in enhanced insulin signaling and fatty acid oxidation [23].
We utilized a P. aeruginosa PA01 STM mutant library [17], [19] and a SP-A deficient mouse model to identify putative microbial targets for SP-A.
It has been recently demonstrated that in a vitamin-A deficient animal model, which lacks biologically active retinoic acid (RA), HEX expression is affected [ 23].
In this study, we have generated an inducible Jak2 deficient model by crossing Jak2fl/fl mice with Cre-ERT2 transgenic mice.
46 49 Interestingly, NAFLD patients with mixed or mesenchymal iron overload (a pattern of iron deposition consistent with a "hepcidin-excess model") seem more likely to develop fibrosis than those with pure parenchymal iron deposits (a pattern of iron deposition consistent with a "hepcidin-deficient model").
Richter et al. found in a surfactant-deficient model of lung injury in sheep that PP improved gas exchange by restoring aeration and decreasing shunt.
Examination of a Neb-deficient model suggests this mechanism may be common in nemaline myopathy.
To further investigate the pro-fibrotic mechanism induced by LPS and related to the activation of M2 macrophages, we tested chronic LPS exposure in a macrophage-deficient model.
To explore the importance of monocytes/macrophages, we used a macrophage-deficient model achieved by diphtheria toxin (DT) treatment of mice selectively expressing the diphtheria toxin receptor in CD11b + cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com