These data was further confirmed by xenograft animal models, which demonstrated that tumors generated from filamin-A deficient cells displayed a better response to chemotherapy [ 127].
LYT1-deficient parasites are infection deficient, display accelerated in vitro development, and have diminished hemolytic activity in acidic conditions [ 2].
TNF-a-deficient mice displayed fewer secondary and tertiary branches of the mammary epithelium during puberty; nevertheless, their lactational capability remained normal [ 101].
In various conditions where high energy levels are required, in general, ERRα-null mice display a deficient biological response compared with their wild-type littermates.
Concomitantly, only cells lacking Moe1 have altered levels of Atf1, and display a deficient activation of Sty1 (Figure 4B and 4C).
We also obtained independent evidence that Xenopus Pol κ-immunodepleted extracts display a deficient ATR/Chk1 signalling pathway by monitoring replication of chromatin containing UV blocking lesions which leads to DNA synthesis slow down (Lupardus et al, 2002; Byun et al, 2005).
The serum from all animals (except from the serum of a CD40L deficient mouse) displayed a complement-mediated bactericidal activity against C. rodentium.
SIRT6 deficient mice display a premature aging-phenotype and die rapidly after birth, displaying an acute multi-organ degenerative syndrome [ 46].
In rice, a BR-deficient mutant displayed erect leaves, reduced plant height, and decreased tiller number and grain size (Yang et al. 2011).
Accordingly, MST1 deficient animals display a range of lymphocyte associated defects, ranging from defective lymphocyte trafficking to impaired development and function of regulatory T cells (summarised in Table 1).
Moreover, GCK-1 deficient animals display a significant increase in germ cell death.
