Thus, upregualated miR-709 and miR-449 in aging LCs may downregulate the expression of IFR and CSFR, causing a deficiency in LCs development in aging mice.
Because the underlying defect would be a deficiency in pancreas development, we would not expect, based on the fetal insulin hypothesis, that increased adiposity is a mediator between low birth weight and type 2 diabetes later in life.
Previous studies showed that the degeneration of chondrocytes was caused by a deficiency in Golgi apparatus development, which could be in charge of sugar synthesis and protein transport in chondrocytes [ 36].
The fact that tpp1− cells show a deficiency in spore production during development indicates that the lysosomal protease ddTpp1 has some fitness-increasing function during development.
The results of this study are consistent with the growing body of evidence for the role of vitamin D deficiency in development of coronary atherosclerosis.
Together these observations suggest that the positioning of the maxillary alveolus and deficiency in development of the palatine plate contribute to the differences in the effects of the two FGFR2 mutations.
To provide a preliminary investigation, we examined the visual cortex organization in the subgroup of subjects suffering from microphthalmia, a developmental deficiency in eye development that leads to the development of smaller (and in this case non-functional) eyes.
New York, New York, January 3, 2000 – Vitamin A deficiency during fetal development and mutations in ret, the gene that encodes an enzyme called a receptor tyrosine kinase, are associated with kidney malformations in mice and humans.
A marked deficiency in OB development has previously been reported in the Prokr2 null mice as early as E16.5 (Matsumoto et al., 2006) and P1 (M.A.C., unpublished observations), suggesting that Prokr2 is critical for the normal development of the OB.
Developmental psychologists study the progression of impulse control and delay of gratification over the lifespan, including deficiencies in development that are closely related to attention deficits and behavior problems.
The follitropin receptor knockout (FORKO) mouse is a genetic model that leads to chronic estrogen deficiency early in development [ 99, 100].
