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It is well established that a defective status of the DNA repair machinery (especially BRCA1/2 genes) correlates with a better response to platinum-based therapy [ 30].
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Hence, deeper understanding of the molecular mechanisms of apoptosis and its defective status opens the gate for a new class of targeted therapeutics.
This suggests that the signaling events downstream of Lif are a key element to the mechanism by which cells sense the defective status of Bmpr1a− / − ESCs.
Mitochondrial cytochrome c (cyt. c) release and caspase activation are often impaired in tumors with Bcl-2 overexpression or Bax and Bak-defective status.
Correcting a defective gene.
A defective factory part, probably".
Is Fosamax a defective product?
Was there a defective chromosome?
But this is a defective analogy.
He readily acknowledged having a "defective education".
(A defective screw, it turns out).
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CEO of Professional Science Editing for Scientists @ prosciediting.com