The phrase "a defect of a component" is correct and usable in written English.
It can be used when discussing issues or problems related to a specific part or element of a larger system or product.
Example: "The engineer identified a defect of a component that was causing the machine to malfunction."
Alternatives: "a flaw in a component" or "an issue with a component".
Within a gene, deleterious mutations can be rectified or compensated by other mutations; within a complex or a network, defects of a component may be compensated by changes on other components.
For example, a defect of function in the TGF- β signalling component leads to carcinogenesis by acting as a definite tumour suppressor during the early phase, but it may exhibit an oncogenic function during later clinical stages (Jakowlew, 2006).
DOI: http://dx.doi.org/10.7554/eLife.02784.007 Retention of PC VII in the ER, upon knockdown of SLY1 or TANGO1, is therefore not because of a defect in cycling of a component that is specifically required for the constitutive trafficking between the ER and the early Golgi cisternae.
Glutamatergic dysfunction has been suggested to be the basis of the pathophysiology of schizophrenia (Tamminga, 1998; Meador-Woodruff and Healy, 2000; Goff and Coyle, 2001), but it is not clear whether glutamatergic hypofunction results from a primary defect in NMDA receptors or from a defect in one component of NMDA receptor-mediated intracellular signal transduction.
In CGD there is a gross defect of components of the NADPH oxidase that is responsible for the respiratory burst in neutrophils.
Concurrently, we see a reduction of the Cu in the O1s and CuLMM spectra during vacuum annealing and the appearance of a defect related component at 191.9/399.3 eV.
The phenotype of the adult onset forms of canine DCM in most breeds is consistent with a defect in components of the cytoskeleton.
In the congenital type, there is a defect in the AV component of the membranous septum, resulting in direct shunting from the LV to the RA, above the hinge points of the tricuspid valve leaflets.
In vitro, neurons from Loa/Loa embryos exhibited a defect in the fast component of retrograde transport without other alterations in the ubiquitous functions of dynein, such as nuclear motility and Golgi complex morphology and positioning.
It may occur as an isolated anomaly, as part of generalized ocular development defects, or as a component of a multisystem disorder [ 24].
