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However, when a defect occurs in one of the enzymes involved in HR, the DSBs are repaired by error prone mechanisms, mostly NHEJ, resulting in an increased risk of new chromosomal defects, and, therefore, the development of cancer [ 70].
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Additionally, where a defect occurred in a single quadrant, it was often in the inferior quadrant.
Cytoplasmic male sterility (CMS) is a defect occurring in plant mitochondria that leads to loss of pollen development and thus, male sterility.
Wyburn-Mason syndresultssults from a defect occurring during embryonic development of the vascular mesoderm, related to the visual pathways passing from the retina to the mesencephalon [ 3].
The loss of iodide uptake capacity in poorly differentiated thyroid carcinomas is mainly due to the reduced/lost functional expression of the sodium/iodide symporter (NIS), with a defect occurring mainly at gene expression level, but in some case involving post-transcriptional or other unknown alterations [ 4- 7].
The electromagnetic field of the motor is redistributed periodically when a geometric defect occurs on a rotating part of the global system.
Taken together, our results suggest that a serious defect occurs in the biosynthesis of TPH2 in the DR following MDMA administration.
When such a distributive defect occurs, increased cardiac output is ineffective in resolving the regional tissue dysoxia.
A second defect occurs in the glpFKX operon and might contribute to the glycerol-negative phenotype as well: both the hypothetical protein glpX (YPO0089) and, more importantly, the glycerol kinase glpK (YPO0090) have also been disrupted by large deletions and are presumed to be pseudogenes.
Small airway disease is also well demonstrated in interstitial pneumonias [ 24], suggesting a mixed defect when an additional restrictive defect occurs as observed in our study.
To demonstrate if a NF- kB defect occurs in DS, we choose to analyse the down-stream product of the NF- kB cascade, i.e. the behaviour of p50/p65 and of its inhibitors in DS cell lines.
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