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Low levels of progesterone and absence of pregnancy may be due to a defect in the mechanism that converts granulosa and theca-lutein cells to luteal cells after the luteinizing hormone surge (or hCG administration).
A possible explanation for our findings is that dSdc mutant flies have a defect in the mechanism(s) involved in dFoxO translocation and transcriptional regulation.
Those with the polymorphism had only half the FAAH enzymatic activity of controls, thus providing substantial evidence for an upregulation of the endocannabinoid system in obesity due to, at least in part, a defect in the mechanism of degradation (60).
This is postulated to occur due to a defect in the mechanism of transport of this sugar from the blood stream into the cells of the liver.
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A plausible explanation for the abnormal activation of CD4+ T cells in TLT could be relative to a defect in the mechanisms controlling the T cell response in this "non-professional" inflammatory-induced lymphoid tissue.
This suggests a defect in the molecular mechanism of action of androgens in PCa.
Current observations have led to a general consensus that CD4 and CD8 T cell activation and turnover are heightened in HIV infection, that HIV infection leads to increased death of CD4+ T cells, that there is a defect in the renewal/replacement mechanisms for CD4+ T cells and that these replacement mechanisms have both peripheral and thymic components.
Our preliminary findings suggest that the oversized immune response in TLT is the consequence of a defect in the regulatory mechanisms.
Now, scientists have identified an enzyme that may link a tumor's ability to spread with a defect in the self-destruct mechanism built into all cells.
Severe injury causes a defect in the blood clotting mechanisms, just when the body really needs them most.
Moreover, because of a defect in the microvasculature, autoregulatory mechanisms are no longer effective in matching oxygen need to oxygen supply and there is an increased shunt of the microcirculation.
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